| The eigen higher criticism and eigen Berk–Jones tests for multiple trait association studies based on GWAS summary statistics |
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| Issue Information |
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| A Bayesian hierarchically structured prior for gene‐based association testing with multiple traits in genome‐wide association studies |
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| A large‐scale transcriptome‐wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine‐mapping |
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54,542 Europeans; up to 35,900 Europeans |
| Precisely modeling zero‐inflated count phenotype for rare variants |
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| Penalized mediation models for multivariate data |
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| REHE: Fast variance components estimation for linear mixed models |
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| Robust estimates of heritable coronary disease risk in individuals with type 2 diabetes |
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| Mendelian randomization in the multivariate general linear model framework |
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African Americans |
| Abstracts |
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| Issue Information |
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| Multi‐marker genetic association and interaction tests with interval‐censored survival outcomes |
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| Block coordinate descent algorithm improves variable selection and estimation in error‐in‐variables regression |
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| Covariate adjusted inference of parent‐of‐origin effects using case–control mother–child paired multilocus genotype data |
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| Issue Information |
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| Taking population stratification into account by local permutations in rare‐variant association studies on small samples |
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ancestry‐based neighbors; population stratification (PS) |
| Random effect based tests for multinomial logistic regression in genetic association studies |
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| InTACT: An adaptive and powerful framework for joint‐tissue transcriptome‐wide association studies |
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| A novel transcriptional risk score for risk prediction of complex human diseases |
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| The X factor: A robust and powerful approach to X‐chromosome‐inclusive whole‐genome association studies |
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| Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals |
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European ancestry; European individuals |
| Identifying genetic risk variants associated with brain volumetric phenotypes via K‐sample Ball Divergence method |
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| Assisted differential network analysis for gene expression data |
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| Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Stu |
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European Americans |
| Genome‐wide association analysis of COVID‐19 mortality risk in SARS‐CoV‐2 genomes identifies mutation in the SARS‐CoV‐2 spike protein that colocalizes with P.1 of the Brazilian strain |
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| Issue Information |
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| Assumptions about frequency‐dependent architectures of complex traits bias measures of functional enrichment |
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| Inverse probability weighting is an effective method to address selection bias during the analysis of high dimensional data |
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| <i>FAT4</i> identified as a potential modifier of orofacial cleft laterality |
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| Testing and estimation of X‐chromosome SNP effects: Impact of model assumptions |
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| Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study |
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| Multitrait transcriptome‐wide association study (TWAS) tests |
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| Caution against examining the role of reverse causality in Mendelian Randomization |
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| Issue Information |
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| Evaluation of saliva as a source of accurate whole‐genome and microbiome sequencing data |
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| A novel Mendelian randomization method with binary risk factor and outcome |
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African Americans |
| Penalized linear mixed models for structured genetic data |
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population structure; population; relatedness |
| The Translational Machine: A novel machine‐learning approach to illuminate complex genetic architectures |
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| A robust two‐sample transcriptome‐wide Mendelian randomization method integrating GWAS with multi‐tissue eQTL summary statistics |
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| Issue Information |
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| Incorporating European GWAS findings improve polygenic risk prediction accuracy of breast cancer among East Asians |
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European (EUR) populations; European (EUR) GWAS; EUR |
| Gene‐based analysis of bi‐variate survival traits via functional regressions with applications to eye diseases |
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| Issue Information |
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| Variant‐set association test for generalized linear mixed model |
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| A Bayesian hierarchically structured prior for rare‐variant association testing |
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| Assisted estimation of gene expression graphical models |
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| Mendelian randomisation with coarsened exposures |
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| Issue Information |
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| Unsupervised cluster analysis of SARS‐CoV‐2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS‐CoV‐2 virus |
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| The utility of the Laplace effect size prior distribution in Bayesian fine‐mapping studies |
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