| Ordered multinomial regression for genetic association analysis of ordinal phenotypes at Biobank scale |
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| Multi‐ethnic analysis shows genetic risk and environmental predictors interact to influence 25(OH)D concentration and optimal vitamin D intake |
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European ancestries; European-ancestry participants |
| An adaptive test for meta‐analysis of rare variant association studies |
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✓ |
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✓ |
European‐ancestry subjects; African‐ancestry subjects |
| An efficient integrative resampling method for gene–trait association analysis |
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| Some statistical consideration in transcriptome‐wide association studies |
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| Integrating germline and somatic genetics to identify genes associated with lung cancer |
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| Powerful rare variant association testing in a copula‐based joint analysis of multiple phenotypes |
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| Critical evaluation of copy number variant calling methods using DNA methylation |
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| Identification of gene–environment interactions with marginal penalization |
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| A flexible and nearly optimal sequential testing approach to randomized testing: QUICK‐STOP |
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| Issue Information |
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| Case‐control versus case‐only estimates of gene‐environment interactions with common and misclassified clinical diagnosis |
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| Transethnic meta‐analysis of metabolic syndrome in a multiethnic study |
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✓ |
✓ |
✓ |
European‐American; African‐American; Japanese‐American; Mexican‐American |
| Population genetic simulation study of power in association testing across genetic architectures and study designs |
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| Embracing study heterogeneity for finding genetic interactions in large‐scale research consortia |
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| Issue Information |
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| Summary statistic analyses can mistake confounding bias for heritability |
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| Joint analysis of multiple phenotypes using a clustering linear combination method based on hierarchical clustering |
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| Invited Abstract |
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| Bivariate logistic Bayesian LASSO for detecting rare haplotype association with two correlated phenotypes |
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| Population‐wide copy number variation calling using variant call format files from 6,898 individuals |
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✓ |
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four European cohorts |
| Combining sequence data from multiple studies: Impact of analysis strategies on rare variant calling and association results |
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| Genome‐wide association study of circulating folate one‐carbon metabolites |
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✓ |
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individuals of European ancestry |
| Gene‐based association analysis of survival traits via functional regression‐based mixed effect cox models for related samples |
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| A general statistic to test an optimally weighted combination of common and/or rare variants |
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| Estimation of DNA contamination and its sources in genotyped samples |
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| Meta‐MultiSKAT: Multiple phenotype meta‐analysis for region‐based association test |
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| Leveraging cell‐specific differentially methylated regions to identify leukocyte infiltration in adipose tissue |
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| Effect of population stratification on SNP‐by‐environment interaction |
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| Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes |
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| Issue Information |
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| Cover Image |
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| Powerful statistical method to detect disease‐associated genes using publicly available genome‐wide association studies summary data |
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| Analytical strategies to include the X‐chromosome in variance heterogeneity analyses: Evidence for trait‐specific polygenic variance structure |
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✓ |
✓ |
Estonian; Multi-Ethnic Study of Atherosclerosis (MESA); UK Biobank (UKB) |
| iFunMed: Integrative functional mediation analysis of GWAS and eQTL studies |
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| Modelling RNA‐Seq data with a zero‐inflated mixture Poisson linear model |
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| A flexible and parallelizable approach to genome‐wide polygenic risk scores |
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| Heritability estimation of dichotomous phenotypes using a liability threshold model on ascertained family‐based samples |
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Korean |
| Bayesian variable selection using partially observed categorical prior information in fine‐mapping association studies |
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| Using GWAS top hits to inform priors in Bayesian fine‐mapping association studies |
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| PAMAM: Power analysis in multiancestry admixture mapping |
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✓ |
✓ |
African American and Latinos |
| Heritability analysis of nontraditional glycemic biomarkers in the Atherosclerosis Risk in Communities Study |
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✓ |
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| Issue Information |
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| A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals |
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| A comparison of two workflows for regulome and transcriptome‐based prioritization of genetic variants associated with myocardial mass |
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| Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer's risk factors among 1,111 cohort participants |
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✓ |
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| Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI |
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| Rare variant association testing for multicategory phenotype |
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| Issue Information |
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| Exome chip‐driven association study of lipidemia in >14,000 Koreans and evaluation of genetic effect on identified variants between different ethnic groups |
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✓ |
✓ |
Asian-specific; ethnic groups; race, sex, age, and ethnicity; Koreans |
| Correlations between relatives: From Mendelian theory to complete genome sequence |
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| Implementing MR‐PRESSO and GCTA‐GSMR for pleiotropy assessment in Mendelian randomization studies from a practitioner's perspective |
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| On the differences between mega‐ and meta‐imputation and analysis exemplified on the genetics of age‐related macular degeneration |
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| Imputed gene associations identify replicable <i>trans</i>‐acting genes enriched in transcription pathways and complex traits |
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| Common genetic variants have associations with human cortical brain regions and risk of schizophrenia |
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| Subset testing and analysis of multiple phenotypes |
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| Bayesian meta‐analysis across genome‐wide association studies of diverse phenotypes |
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| A simple approximation to bias in the genetic effect estimates when multiple disease states share a clinical diagnosis |
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| Ancestry‐specific association mapping in admixed populations |
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✓ |
✓ |
admixed populations; ancestral populations; ancestry; Greenlandic population |
| Issue Information |
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| A network approach to prioritizing susceptibility genes for genome‐wide association studies |
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| Extended methods for gene–environment‐wide interaction scans in studies of admixed individuals with varying degrees of relationships |
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✓ |
✓ |
mentions 'African Americans', 'admixed individuals/populations', and 'measures of genome-wide ancest |
| Robust meta‐analysis of biobank‐based genome‐wide association studies with unbalanced binary phenotypes |
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| Gene–environment interactions related to blood pressure traits in two community‐based Korean cohorts |
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| Issue Information |
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| Robust network‐based regularization and variable selection for high‐dimensional genomic data in cancer prognosis |
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| Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease |
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| Familial recurrence risk with varying amount of family history |
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| Presidential address: Six open questions to genetic epidemiologists |
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| A large‐scale exome array analysis of venous thromboembolism |
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✓ |
✓ |
✓ |
European ancestry; African American ancestry |
| A finite mixture model for X‐chromosome association with an emphasis on microbiome data analysis |
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| Spinning convincing stories for both true and false association signals |
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| A fully adjusted two‐stage procedure for rank‐normalization in genetic association studies |
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| Issue Information |
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| Constrained instruments and their application to Mendelian randomization with pleiotropy |
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| Application of deep convolutional neural networks in classification of protein subcellular localization with microscopy images |
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| A simple and accurate method to determine genomewide significance for association tests in sequencing studies |
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| A simple approximation to the bias of gene–environment interactions in case–control studies with silent disease |
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| Exact variance component tests for longitudinal microbiome studies |
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| A comparison of popular TDT‐generalizations for family‐based association analysis |
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| A review of kernel methods for genetic association studies |
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