| Rare variant association test with multiple phenotypes |
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| Evidence for SNP-SNP interaction identified through targeted sequencing of cleft case-parent trios |
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| Impact of genotyping errors on statistical power of association tests in genomic analyses: A case study |
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| Integration of gene expression and methylation to unravel biological networks in glioblastoma patients |
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| A small-sample multivariate kernel machine test for microbiome association studies |
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| Resetting the bar: Statistical significance in whole‐genome sequencing‐based association studies of global populations |
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sequencing efforts in >2,000 samples of European, Asian, or admixed ancestry; Asian, admixed ancestry, African samples |
| Issue Information |
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| Fast Genome‐Wide QTL Association Mapping on Pedigree and Population Data |
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| Genome‐wide survey in African Americans demonstrates potential epistasis of fitness in the human genome |
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African Americans; admixed population; local ancestry |
| A comparison study of multivariate fixed models and Gene Association with Multiple Traits (GAMuT) for next‐generation sequencing |
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✓ |
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European cohorts |
| Leveraging population information in family‐based rare variant association analyses of quantitative traits |
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| Whole exome association of rare deletions in multiplex oral cleft families |
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| A general approach to testing for pleiotropy with rare and common variants |
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| Multiple linear combination (MLC) regression tests for common variants adapted to linkage disequilibrium structure |
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| Use of big data for drug development and for public and personal health and care |
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| A method for integrating neuroimaging into genetic models of learning performance |
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✓ |
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European individuals |
| Practical aspects of gene regulatory inference via conditional inference forests from expression data |
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| Issue Information |
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| Sparse multivariate factor analysis regression models and its applications to integrative genomics analysis |
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| PreCimp: Pre‐collapsing imputation approach increases imputation accuracy of rare variants in terms of collapsed variables |
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| Exome copy number variation detection: Use of a pool of unrelated healthy tissue as reference sample |
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| Longitudinal SNP‐set association analysis of quantitative phenotypes |
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| Mendelian randomization analysis of a time‐varying exposure for binary disease outcomes using functional data analysis methods |
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| Low-, high-coverage, and two-stage DNA sequencing in the design of the genetic association study |
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| Issue Information |
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| The 2016 Annual Meeting of the International Genetic Epidemiology Society |
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| Validity of using ad hoc methods to analyze secondary traits in case‐control association studies |
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| Bias due to participant overlap in two‐sample Mendelian randomization |
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| When do myopia genes have their effect? Comparison of genetic risks between children and adults |
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| Identifying significant gene‐environment interactions using a combination of screening testing and hierarchical false discovery rate control |
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| P129 Role of telomere length within the complex relationship between genetic traits and environmental/occupational exposures in bladder cancer risk |
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| Efficient unified rare variant association test by modeling the population genetic distribution in case‐control studies |
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| A W‐test collapsing method for rare‐variant association testing in exome sequencing data |
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| A meta‐analytic framework for detection of genetic interactions |
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✓ |
✓ |
ancestral differences; population structure; populations; highly differentiated populations |
| Issue Information |
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| Prioritizing individual genetic variants after kernel machine testing using variable selection |
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| Toward the integration of <i>Omics</i> data in epidemiological studies: still a “long and winding road” |
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| A perspective on interaction effects in genetic association studies |
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| A global test for gene‐gene interactions based on random matrix theory |
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| Obesity and associated lifestyles modify the effect of glucose metabolism‐related genetic variants on impaired glucose homeostasis among postmenopausal women |
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| A Comparison Study of Fixed and Mixed Effect Models for Gene Level Association Studies of Complex Traits |
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| <i>FARVATX</i>: Family‐Based Rare Variant Association Test for X‐Linked Genes |
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| A Clustered Multiclass Likelihood‐Ratio Ensemble Method for Family‐Based Association Analysis Accounting for Phenotypic Heterogeneity |
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| Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case‐Control Sequencing Studies |
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| Family‐Based Rare Variant Association Analysis: A Fast and Efficient Method of Multivariate Phenotype Association Analysis |
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| Exposure Enriched Case‐Control (EECC) Design for the Assessment of Gene–Environment Interaction |
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| Issue Information |
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| Meta‐Analysis of Genome‐Wide Association Studies with Correlated Individuals: Application to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) |
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✓ |
✓ |
Hispanic; ancestry group; Study of Latinos; Latinos |
| G‐STRATEGY: Optimal Selection of Individuals for Sequencing in Genetic Association Studies |
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| Identification of Rare Variants in Metabolites of the Carnitine Pathway by Whole Genome Sequencing Analysis |
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| Analyzing Association Mapping in Pedigree‐Based GWAS Using a Penalized Multitrait Mixed Model |
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| Determining Which Phenotypes Underlie a Pleiotropic Signal |
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| An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene‐Lifestyle Interactions Working Group |
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✓ |
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European ancestry |
| Using Whole Exome Sequencing to Identify Candidate Genes With Rare Variants In Nonsyndromic Cleft Lip and Palate |
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✓ |
✓ |
Amerindian populations; Honduran population |
| Association Between Absolute Neutrophil Count and Variation at <i>TCIRG1</i>: The NHLBI Exome Sequencing Project |
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| A Critical Look at Entropy‐Based Gene‐Gene Interaction Measures |
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| Detecting Gene–Environment Interactions for a Quantitative Trait in a Genome‐Wide Association Study |
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✓ |
✓ |
Hispanic‐ethnicity |
| Penetrance of <i>ATM</i> Gene Mutations in Breast Cancer: A Meta‐Analysis of Different Measures of Risk |
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| An Object‐Oriented Regression for Building Disease Predictive Models with Multiallelic HLA Genes |
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| Issue Information |
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| Polygenic Epidemiology |
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| Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator |
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| Evaluation of a Two‐Stage Approach in Trans‐Ethnic Meta‐Analysis in Genome‐Wide Association Studies |
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| Studying the Genetics of Complex Disease With Ancestry‐Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations |
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✓ |
✓ |
✓ |
European ancestry counterparts; East Asians; East Asian HPN; East Asian populations; ancestry-specific |
| Review of the Gene‐Environment Interaction Literature in Cancer: What Do We Know? |
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| Across‐Platform Imputation of DNA Methylation Levels Incorporating Nonlocal Information Using Penalized Functional Regression |
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| Testing Allele Transmission of an SNP Set Using a Family‐Based Generalized Genetic Random Field Method |
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| Uncovering Local Trends in Genetic Effects of Multiple Phenotypes via Functional Linear Models |
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| Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses |
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| Bayesian Variable Selection in Multilevel Item Response Theory Models with Application in Genomics |
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| Issue Information |
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| JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects |
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| eQuIPS: eQTL Analysis Using Informed Partitioning of SNPs – A Fully Bayesian Approach |
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| General Framework for Meta‐Analysis of Haplotype Association Tests |
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| Smooth-Threshold Multivariate Genetic Prediction with Unbiased Model Selection |
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| Binomial Mixture Model Based Association Testing to Account for Genetic Heterogeneity for GWAS |
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| Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach |
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| Issue Information |
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| Contents |
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| Generalization of Rare Variant Association Tests for Longitudinal Family Studies |
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| Gene-Based Association Analysis for Censored Traits Via Fixed Effect Functional Regressions |
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| Sequence Kernel Association Test of Multiple Continuous Phenotypes |
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