| A Novel Test for Testing the Optimally Weighted Combination of Rare and Common Variants Based on Data of Parents and Affected Children |
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| Regularized Rare Variant Enrichment Analysis for Case‐Control Exome Sequencing Data |
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| George Bonney (1947–2013) Remembered |
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| Semiparametric Tests for Identifying Differentially Methylated Loci With Case–Control Designs Using Illumina Arrays |
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| A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity |
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| A Variational Bayes Discrete Mixture Test for Rare Variant Association |
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✓ |
✓ |
African Americans |
| Detecting Rare Haplotype‐Environment Interaction With Logistic Bayesian LASSO |
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| Efficient Strategy for Detecting Gene × Gene Joint Action and Its Application in Schizophrenia |
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| Genetic Prediction of Quantitative Lipid Traits: Comparing Shrinkage Models to Gene Scores |
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| Identification of New Genetic Susceptibility Loci for Breast Cancer Through Consideration of Gene‐Environment Interactions |
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✓ |
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of European ancestry |
| Robust Rare Variant Association Testing for Quantitative Traits in Samples With Related Individuals |
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| Power of Family‐Based Association Designs to Detect Rare Variants in Large Pedigrees Using Imputed Genotypes |
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| A General Framework for Association Tests With Multivariate Traits in Large‐Scale Genomics Studies |
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| Statistical Testing of Shared Genetic Control for Potentially Related Traits |
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| Distinct Loci in the <i>CHRNA5</i>/<i>CHRNA3</i>/<i>CHRNB4</i> Gene Cluster Are Associated With Onset of Regular Smoking |
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| Quantitative Allelic Test—A Fast Test for Very Large Association Studies |
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| Identifying Rare Variants With Optimal Depth of Coverage and Cost‐Effective Overlapping Pool Sequencing |
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| GEE‐Based SNP Set Association Test for Continuous and Discrete Traits in Family‐Based Association Studies |
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| Strategies for Developing Prediction Models From Genome‐Wide Association Studies |
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| A Robust Method for Genome‐Wide Association Meta‐Analysis With the Application to Circulating Insulin‐Like Growth Factor I Concentrations |
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| Richard M. Simon. <i>Genomic Clinical Trials and Predictive Medicine</i>. Cambridge University Press, New York, 2013, xiv+144 pages. ISBN 978‐1‐107‐00880‐9 (Hardback). ISBN 978‐1‐107‐40135‐8 (Paperbac |
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| Functional Linear Models for Association Analysis of Quantitative Traits |
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| BRCA1 polymorphisms and breast cancer epidemiology in the Western New York Exposures and Breast Cancer (WEB) study |
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| Gene‐Environment Interactions in Cancer Epidemiology: A National Cancer Institute Think Tank Report |
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| A Whole‐Genome Simulator Capable of Modeling High‐Order Epistasis for Complex Disease |
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| Adjusting for Population Stratification in a Fine Scale With Principal Components and Sequencing Data |
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✓ |
✓ |
population stratification; population structures; ethnic subgroups; human evolution history |
| Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data |
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| A Powerful Method for Combining <i>P</i>‐Values in Genomic Studies |
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| Genome‐Wide Association Study of a Heart Failure Related Metabolomic Profile Among African Americans in the Atherosclerosis Risk in Communities (ARIC) Study |
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✓ |
✓ |
African Americans |
| A Multiclass Likelihood Ratio Approach for Genetic Risk Prediction Allowing for Phenotypic Heterogeneity |
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| A Shrinkage Method for Testing the Hardy–Weinberg Equilibrium in Case‐Control Studies |
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| EINVis: A Visualization Tool for Analyzing and Exploring Genetic Interactions in Large‐Scale Association Studies |
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| Empirical Hierarchical Bayes Approach to Gene‐Environment Interactions: Development and Application to Genome‐Wide Association Studies of Lung Cancer in TRICL |
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| Ridge Regression in Prediction Problems: Automatic Choice of the Ridge Parameter |
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| Finding Novel Genes by Testing G × E Interactions in a Genome‐Wide Association Study |
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| A Kernel Regression Approach to Gene‐Gene Interaction Detection for Case‐Control Studies |
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| VAAST 2.0: Improved Variant Classification and Disease‐Gene Identification Using a Conservation‐Controlled Amino Acid Substitution Matrix |
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| The Value of Statistical or Bioinformatics Annotation for Rare Variant Association With Quantitative Trait |
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| Identification of Grouped Rare and Common Variants via Penalized Logistic Regression |
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| Statistical Genetic Analysis of Serological Measures of Common, Chronic Infections in Alaska Native Participants in the GOCADAN Study |
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| Novel Likelihood Ratio Tests for Screening Gene‐Gene and Gene‐Environment Interactions With Unbalanced Repeated‐Measures Data |
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| Recommended Joint and Meta‐Analysis Strategies for Case‐Control Association Testing of Single Low‐Count Variants |
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| Testing for Rare Variant Associations in the Presence of Missing Data |
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| Encore: Genetic Association Interaction Network Centrality Pipeline and Application to SLE Exome Data |
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| Haplotype Kernel Association Test as a Powerful Method to Identify Chromosomal Regions Harboring Uncommon Causal Variants |
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| Characterization and Correction of Error in Genome‐Wide IBD Estimation for Samples with Population Structure |
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| Genetic Association With Multiple Traits in the Presence of Population Stratification |
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| SBERIA: Set‐Based Gene‐Environment Interaction Test for Rare and Common Variants in Complex Diseases |
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| Using Phenotypic Heterogeneity to Increase the Power of Genome‐Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes |
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| <i>BRCA1</i> Polymorphisms and Breast Cancer Epidemiology in the Western New York Exposures and Breast Cancer (WEB) Study |
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| On Association Analysis of Rare Variants Under Population Substructure: An Approach for the Detection of Subjects That Can Cause Bias in the Analysis—T<sub>opt</sub>: An Outlier Detection Method |
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| Multiple Genetic Variant Association Testing by Collapsing and Kernel Methods With Pedigree or Population Structured Data |
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| A Genome‐Wide Association Study for Venous Thromboembolism: The Extended Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium |
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|
✓ |
|
|
individuals of European ancestry |
| Pathway‐Based Approaches for Sequencing‐Based Genome‐Wide Association Studies |
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| Testing for Modes of Inheritance Involving Compound Heterozygotes |
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| Efficient Two‐Step Testing of Gene‐Gene Interactions in Genome‐Wide Association Studies |
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| Strategy to Control Type I Error Increases Power to Identify Genetic Variation Using the Full Biological Trajectory |
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| Genetic Association Analysis and Meta‐Analysis of Imputed SNPs in Longitudinal Studies |
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| A Method to Detect Differentially Methylated Loci With Next‐Generation Sequencing |
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| Making Medical Decisions in Dependence of Genetic Background: Estimation of the Utility of <scp>DNA</scp> Testing in Clinical, Pharmaco‐Epidemiological or Genetic Studies |
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| African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations |
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✓ |
|
|
The European component varied from 0.14 ± 0.05 among Jamaicans and Barbadians to 0.26 ± 0.08 among C |
| Adjusted Sequence Kernel Association Test for Rare Variants Controlling for Cryptic and Family Relatedness |
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| The Impact of Improved Microarray Coverage and Larger Sample Sizes on Future Genome‐Wide Association Studies |
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| A Geometric Framework for Evaluating Rare Variant Tests of Association |
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| Rank‐Based Robust Tests for Quantitative‐Trait Genetic Association Studies |
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| A Nonparametric Test to Detect Quantitative Trait Loci Where the Phenotypic Distribution Differs by Genotypes |
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| The Case‐Only Test for Gene–Environment Interaction is Not Uniformly Powerful: An Empirical Example |
|
|
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|
|
✓ |
✓ |
Chinese populations |
| A Unified Mixed‐Effects Model for Rare‐Variant Association in Sequencing Studies |
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| Sample Size Considerations of Prediction‐Validation Methods in High‐Dimensional Data for Survival Outcomes |
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| Marbled Inflation From Population Structure in Gene‐Based Association Studies With Rare Variants |
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| Vi<scp>SEN</scp>: Methodology and Software for Visualization of Statistical Epistasis Networks |
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| Kernel Machine SNP‐Set Testing Under Multiple Candidate Kernels |
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| Interpreting Joint <scp>SNP</scp> Analysis Results: When Are Two Distinct Signals Really Two Distinct Signals? |
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| A Genome‐Wide Association Study for Serum Bilirubin Levels and Gene‐Environment Interaction in a Chinese Population |
|
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|
✓ |
✓ |
✓ |
European populations; Han Chinese; Chinese population |
| Extending Admixture Mapping to Nuclear Pedigrees: Application to Sarcoidosis |
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|
✓ |
✓ |
"African Americans" and "African ancestry" |
| A Bivariate Mann‐Whitney Approach for Unraveling Genetic Variants and Interactions Contributing to Comorbidity |
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| Two‐Phase Designs to Follow‐Up Genome‐Wide Association Signals With DNA Resequencing Studies |
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| Association Testing of the Mitochondrial Genome Using Pedigree Data |
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| Importance of Different Types of Prior Knowledge in Selecting Genome‐Wide Findings for Follow‐Up |
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