| Pooling Data and Linkage Analysis in the Chromosome 5q Candidate Region for Asthma |
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| The Effect of Genotype and Pedigree Error on Linkage Analysis: Analysis of Three Asthma Genome Scans |
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| Improved Evidence for Linkage on 6p and 5p with Retrospective Pooling of Data from Three Asthma Genome Screens |
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| Weighting Schemes in Pooled Linkage Analysis |
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| Inclusion of Candidate Region Studies in Meta‐Analysis Using the Genome Screen Meta‐Analysis Method: Application to Asthma Data |
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| An Autosome‐Wide Search for Loci Underlying Wheezing Age of Onset in German Asthmatic Children Identifies a New Region of Interest on 6q24–q25 |
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| Using Data Mining to Address Heterogeneity in the Southampton Data |
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| Triangle Test Statistic in Discordant Sib Pairs: Test of Genetic Heterogeneity of Asthma and Atopy in CSGA Families |
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✓ |
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| Linkage Analysis of Asthma and Atopy Including Models with Genomic Imprinting |
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| A Pedigree Partitioning Approach to Quantitative Trait Loci Mapping of IgE Serum Level in the GAW12 Hutterite Data |
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| Family‐Based Tests of Association in the Presence and Absence of Known Linkage |
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✓ |
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| Transmission/Disequilibrium Test Analysis of Total Serum IgE Levels in the Hutterite and Collaborative Study on the Genetics of Asthma Data Sets |
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| Tree‐Based Linkage and Association Analyses of Asthma |
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| Association Analysis in a Variance Components Framework |
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| Using Step‐Wise Linear Regression to Detect “Functional” Sequence Variants: Application to Simulated Data |
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| Combined Linkage and Association Analysis in Pedigrees |
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| Test of Association for Quantitative Traits in General Pedigrees: The Quantitative Pedigree Disequilibrium Test |
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| Introduction: Transmission/Disequilibrium Test/Association Group |
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| Modeling Complex Disease with Demographic and Environmental Covariates and a Candidate Gene Marker |
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| Applying Data Mining Techniques to the Mapping of Complex Disease Genes |
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| Homogeneity of Asthma Genome Scan Results |
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✓ |
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✓ |
✓ |
African American; German |
| Introduction: Linkage Analysis of Quantitative Traits |
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| Combining Multiple Phenotypic Traits Optimally for Detecting Linkage with Sib‐Pair Observations |
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| Introduction: Linkage Analysis of Discrete Traits |
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| Life After the Screen: Making Sense of Many P‐Values |
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| Maximum Identity Length Contrast: A Powerful Method For Susceptibility Gene Detection in Isolated Populations |
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| Introduction: Analysis of Sequence Data and Population Structure |
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| Selection of Single Nucleotide Polymorphisms for Association Studies in Candidate Genes |
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| Linkage Disequilibrium Structure and Its Impact on the Localization of a Candidate Functional Mutation |
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| Analysis of Nucleotide Sequence Data Using Mixed Model Methodology |
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| Introduction: Bayesian Models and Markov Chain Monte Carlo Methods |
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| Markov Chain Monte Carlo Linkage Analysis of Complex Quantitative Phenotypes |
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| Hierarchical Modeling of the Relation Between Sequence Variants and a Quantitative Trait: Addressing Multiple Comparison and Population Stratification Issues |
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| On the Detection of Linkage in Multiple Data Sets: A Comparison of Various Statistical Approaches |
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| Genome‐Wide Linkage Analysis in a General Population Sample Using σ2A Random Effects (SSARs) Fitted by Gibbs Sampling |
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| Application of a Bayesian Method for Optimal Subset Regression to Linkage Analysis of Q1 and Q2 |
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| Quantitative Trait Linkage Analysis of the Liability Underlying a Common Oligogenic Disease |
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| Introduction: Sampling and Data Structure |
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| Assessing the Effect of Sampling Strategies on the Power of Linkage Analysis to Identify Pathway‐Specific Loci Underlying a Complex Disease |
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| Variance Components Analysis for Genetic Linkage of Time to Onset for Disease |
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| Distribution of lod Scores in Oligogenic Linkage Analysis |
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| A Comparison of Software Packages that Assess Linkage Using a Variance Components Approach |
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| Introduction: Methods for Detecting Genotype × Environment Interaction |
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| Should We Consider Gene×Environment Interaction in the Hunt for Quantitative Trait Loci? |
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| Oxford Genome Screen for Asthma‐Associated Traits |
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| Nonparametric Linkage Regression II: Identification of Influential Pedigrees in Tests for Linkage |
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✓ |
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| Sex‐ and Age‐of‐Onset‐Based Locus Heterogeneity in Asthma |
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| Genetic Analysis of Quantitative Traits in Highly Ascertained Samples: Total Serum IgE in Families with Asthma |
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| Detection of Parent‐of‐Origin Effects for Atopy by Model‐Free and Model‐Based Linkage Analyses |
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| Comparison of Sib Pair‐Based Approaches for Identifying Quantitative Trait Loci Underlying Asthma in the Busselton Families |
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| A Bivariate Haseman‐Elston Method and Application to the Analysis of Asthma‐Related Phenotypes on Chromosome 5q |
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| A Kinship Analysis of Asthma Among the Hutterites |
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| Introduction: Interactions in Asthma |
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| Genome‐Wide Approaches for Identifying Interacting Susceptibility Regions for Asthma |
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| Two‐Trait‐Locus Linkage Analyses of Asthma Susceptibility |
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✓ |
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| Oligogenic Approaches to the Predisposition of Asthma in Ethnically Diverse Populations |
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| Segregation Analysis of Asthma and Respiratory Allergy in Population‐Based Samples of Families |
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✓ |
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| Genome Scan for Linkage to Asthma Using a Linkage Disequilibrium‐lod Score Test |
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✓ |
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| Haplotype Sharing Tests of Linkage Disequilibrium in a Hutterite Asthma Data Set |
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|
✓ |
✓ |
Hutterite population |
| Comparison of the QTDT Analysis for IgE in the CSGA Data Set |
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| Evolution of the Simulated Data Problem |
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| GAW12: Simulated Genome Scan, Sequence, and Family Data for a Common Disease |
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| Detection of Misspecified Relationships in Inbred and Outbred Pedigrees |
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|
✓ |
✓ |
Hutterites |
| Comparison of Novel and Existing Methods for Detection of Linkage Disequilibrium Using Parent‐Child Trios in the GAW12 Genetic Isolate Simulated Data |
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| Preliminary Implementation of New Data Mining Techniques for the Analysis of Simulation Data from Genetic Analysis Workshop 12: Problem 2 |
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| Description of Three Data Sets: Collaborative Study on the Genetics of Asthma (CSGA), the German Affected‐Sib‐Pair Study, and the Hutterites of South Dakota |
|
✓ |
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|
✓ |
✓ |
African American; Hutterite |
| Introduction: Heterogeneity |
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| Identifying Susceptibility Genes Using Linkage and Linkage Disequilibrium Analysis in Large Pedigrees |
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| The Use of Sequential Designs in Genome Scans for Asthma Susceptibility Loci With Affected Sib Pairs |
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| Model‐Free Linkage Analysis: Performance Under Real‐World Conditions |
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| Locating the Genes Underlying a Simulated Complex Disease by Discriminant Analysis |
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| To Type or Not To Type: The Use of Unaffected Siblings in Nonparametric Linkage Analysis |
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| Parametric Linkage Analysis and Disequilibrium Methods to Identify Loci for Complex Disease |
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| Introduction: Haplotype Analysis of Simulated Genetic Analysis Workshop 12 Data |
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| Linkage Disequilibrium Mapping of Complex Genetic Diseases Using Multiallelic Markers |
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| Clustering of Pedigrees Using Marker Allele Frequencies: Impact on Linkage Analysis |
|
✓ |
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|
✓ |
✓ |
African American |
| The Power of Transmission Disequilibrium Tests for Quantitative Traits |
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|
| SNPing Away at Candidate Genes |
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| Common Disease Analysis Using Multivariate Adaptive Regression Splines (MARS): Genetic Analysis Workshop 12 Simulated Sequence Data |
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|
✓ |
✓ |
isolated population |
| Population Based Linkage Disequilibrium Mapping of QTL: An Application to Simulated Data in an Isolated Population |
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|
| Association and Linkage for Age at Onset of a Common Oligogenic Disease Using Genetic Variance Component Models |
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|
| Bayesian Association Mapping for Quantitative Traits in a Mixture of Two Populations |
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|
| Introduction: Phenotype Definition |
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| Comparison of Three Methods for Obtaining Principal Components from Family Data in Genetic Analysis of Complex Disease |
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| Comparison of Variance Components, ANOVA and Regression of Offspring on Midparent (ROMP) Methods for SNP Markers |
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| Gene×Environment Interaction from Case‐Control and Case‐Case Approaches |
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| Impact of Preadjusting a Quantitative Phenotype Prior to Sib‐Pair Linkage Analysis when Gene×Environment Interaction Exists |
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| Investigation of a Candidate Gene, Environment, and G×E Interaction Using Case‐Control and Case‐Parent Study Designs |
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|
| Adaptations of Linkage and Association Methods for the Study of Asthma, A Complex Trait |
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|
|
| Single Region Linkage Analyses of Asthma: Description of Data Sets |
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|
|
| Nonparametric Linkage Regression I: Combined Caucasian CSGA and German Genome Scans for Asthma |
✓ |
✓ |
|
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|
✓ |
✓ |
German |
| Quantitative Trait Loci Mapping of Serum IgE in an Isolated Hutterite Population |
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|
|
| The Effect of Pedigree Complexity on Quantitative Trait Linkage Analysis |
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|
|
| Two‐Locus Modeling of Asthma in a Hutterite Pedigree via Markov Chain Monte Carlo |
|
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|
|
| Incorporating Age at Onset Information into the Transmission/Disequilibrium Test |
|
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|
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|
|
| Introduction: Association and Transmission/Disequilibrium Test Analyses of Discrete Traits in the GAW12 Simulated Data |
|
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|
|
| Two Approaches for Consolidating Results from Genome Scans of Complex Traits: Selection Methods and Scan Statistics |
|
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|
|
| Joint Modeling of Genetic Association and Population Stratification Using Latent Class Models |
|
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|
✓ |
✓ |
"ethnic groups", "immigration" (as source of stratification), "population stratification", "populati |
| A Robust Score Test for Linkage Disequilibrium in General Pedigrees |
|
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|
|
| A Robust Multipoint Linkage Statistic (tlod) for Mapping Complex Trait Loci |
|
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|
|
| Locus Ordering Based on Crossover Information in Family Haplotypes: Application of a “Minimum Break” Algorithm |
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|
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| Mining Associations Between Genetic Markers, Phenotypes, and Covariates |
|
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|
|
| Localization of the Q1 Mutation by Cladistic Analysis |
|
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|
|
| Predicting Quantitative Trait Levels by Modeling SNP Interaction |
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|
|
| Sequence Analysis Using Logic Regression |
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|
|
| Genome Scans for Q1 and Q2 on General Population Replicates Using Loki |
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|
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| Markov Chain Monte Carlo Linkage Analysis: Effect of Bin Width on the Probability of Linkage |
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|
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| Bayes Estimates of Haplotype Effects |
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|
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| Power to Localize the Major Gene for Disease Liability Is Increased After Accounting for the Effects of Related Quantitative Phenotypes |
|
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|
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| Novel Selection Criteria for Genome Scans of Complex Traits |
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|
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| Introduction: Linkage Analysis of Full‐Genome Screens |
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|
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| A Joint Analysis of Asthma Affection Status and IgE Levels in Multiple Data Sets Collected for Asthma |
|
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|
|
| Introduction: Linkage Analyses in Single (Non‐Hutterite) Populations |
|
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|
|
| Multilocus Linkage Analysis of the German Asthma Data |
|
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|
✓ |
✓ |
German (appears as 'German Asthma Data' and 'German Asthma Genetics Group') |
| Introduction: Linkage Analyses in the Hutterites |
|
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|
|
| The Importance of Connections: Joining Components of the Hutterite Pedigree |
|
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|
|
| Pedigree Selection and Tests of Linkage in a Hutterite Asthma Pedigree |
|
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|
✓ |
✓ |
Hutterite; founder population; co-ancestry |
| Marker Selection by Akaike Information Criterion and Bayesian Information Criterion |
|
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|
|
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|
|
| Introduction: Linkage Disequilibrium and Combined Linkage and LD Mapping of Asthma‐Related Genes |
|
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|
|
| Family‐Based Association Tests for Qualitative and Quantitative Traits Using Single‐Nucleotide Polymorphism and Microsatellite Data |
|
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|
|
| The Single‐Nucleotide Polymorphism Lottery: How Useful are a Few Common SNPs in Identifying Disease‐Associated Alleles? |
|
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|
|
| Using Single Nucleotide Polymorphisms to Investigate Association Between a Candidate Gene and Disease |
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|
|
| Exploiting Linkage Disequilibrium in Population Isolates |
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|
|
| Analysis of Single Nucleotide Polymorphisms in Candidate Genes Using the Pedigree Disequilibrium Test |
|
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|
|
| A New Nonparametric Linkage Statistic for Mapping Both Qualitative and Quantitative Trait Loci |
|
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|
|
| Does Simultaneous Consideration of Multiple Regions Improve Disease Gene Localization? |
|
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|
|
| Linkage Analysis of Genetic Analysis Workshop 12 Simulated Data Based on Affected Individuals Only |
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|
|
| Covariates in Linkage Analysis Using Sibling and Cousin Pairs |
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|
|
| Multipoint Linkage Analysis Under Heterogeneity: Incorporation of Parametric and Nonparametric Approaches |
|
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|
✓ |
✓ |
German |
| Exploring Haplotype Sharing Methods in General and Isolated Populations to Detect Gene(s) of a Complex Genetic Trait |
|
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|
|
|
|
|
|
| Genome Scan of Complex Traits by Haplotype Sharing Correlation |
|
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|
|
| Combined Multipoint Analysis of Multiple Asthma Data Sets Based on the Posterior Probability of Linkage |
|
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|
|
| Use of Variable Marker Density, Principal Components, and Neural Networks in the Dissection of Disease Etiology |
|
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|
|
| Comparison of Likelihood Approaches for Combined Segregation and Linkage Analysis of a Complex Disease and a Candidate Gene Marker Under Different Ascertainment Schemes |
|
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|
|
| Introduction: Extensions to Variance Component Methods |
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|
|
| Does Accounting for Mitochondrial Genetic Variation Improve the Fit of Genetic Models? |
|
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|
|
| Linkage Analysis of Quantitative Traits in Randomly Ascertained Pedigrees: Comparison of Penetrance‐Based and Variance Component Analysis |
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|
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|
|
| Introduction: Linkage Analyses of Single Regions |
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|
|
| Detecting Genotype × Age Interaction |
|
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|
|
| Modeling Age×Major Gene Interaction by a Variance Component Approach |
|
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|
|
| Meta‐Analysis of Sib Pair Linkage Studies of Asthma and the Interleukin‐9 Gene (IL9) |
|
|
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|
|
|
|
|
|
| Introduction: First Things First |
|
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|
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|
|
| Detecting Population Outliers and Null Alleles in Linkage Data: Application to GAW12 Asthma Studies |
|
✓ |
|
|
|
|
✓ |
✓ |
African-American; German |
| Introduction: Association and TDT Analyses of Quantitative Traits |
|
|
|
|
|
|
|
|
|
| Two Approaches for Consolidating Results from Genome Scans of Complex Traits: Selection Methods and Scan Statistics |
|
|
|
|
|
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|
|
| Influence of Marker Heterozygosity and Genetic Heterogeneity on Fine Mapping |
|
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|
|
| Replication of Linkage to Quantitative Trait Loci: Variation in Location and Magnitude of the Lod Score |
|
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|
|
| Use of Weighted p‐Values in Regional Inference Procedures |
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|
|
| A Clustering Approach for Localizing Disease Susceptibility Loci |
|
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|
|
| Allelic Association in Large Pedigrees |
|
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|
|
|
|
|
| Cladistic Analysis of Haplotypes as an Attempt to Detect Disease Susceptibility |
|
|
|
|
|
|
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|
|
| Computational Methods for Single‐Point and Multipoint Analysis of Genetic Variants Associated with a Simulated Complex Disorder in a General Population |
|
|
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|
|
| Comparison of Marker Intervals and Number of Sib Pairs Used for Linkage Analysis on Simulated Nuclear Family Data |
|
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|
|
| The Utility of Bayesian Model Averaging for Detecting Known Oligogenic Effects |
|
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|
|
| Practical Application of Residuals from Survival Models in Quantitative Trait Linkage Analysis |
|
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|
|
| Assessing Linkage of Immunoglobulin E Using a Meta‐Analysis Approach |
|
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| Stoppage: An issue for segregation analysis |
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|
|
| Efficient use of siblings in testing for linkage and association |
|
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|
| Book Review |
|
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|
|
| Tree‐based recursive partitioning methods for subdividing sibpairs into relatively more homogeneous subgroups |
|
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|
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| Estimation of allele frequencies with data on sibships |
|
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|
|
| A computationally simple test of homogeneity of odds ratios for twin data |
|
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|
|
| Effect of polygenes on Xiong’s transmission disequilibrium test of a QTL in nuclear families with multiple children |
|
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|
|
| Book Review: Newtonian physic |
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|
|
| A weighted test using both extreme discordant and concordant sib pairs for detecting linkage |
|
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|
|
| Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1 |
|
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| Bayesian oligogenic analysis of quantitative and qualitative traits in general pedigrees |
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| On the total expected study cost in two‐stage genome‐wide search designs for linkage analysis using the mean test for affected sib pairs |
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| Evidence for a major gene influence on abdominal fat distribution: The Minnesota breast cancer family study |
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| Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in central Sardinia |
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| Abstracts from the Tenth Annual Meeting of the International Genetic Epidemiology Society |
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| Key word index |
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| Determining trait locus position from multipoint analysis: Accuracy and power of three different statistics |
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| Segregation analysis of cancer in families of glioma patients |
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| Heritability of plasma amyloid β in typical late‐onset Alzheimer’s disease pedigrees |
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| Genetic epidemiology of visceral leishmaniasis in northeastern Brazil |
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✓ |
✓ |
racial differences |
| Editorial |
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| Consanguinity and the transmission/disequilibrium test for allelic association |
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| Pseudo-likelihood estimates of the cumulative risk of an autosomal dominant disease from a kin-cohort study |
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| Unbiased methods for population‐based association studies |
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| Testing candidate genes for non‐syndromic oral clefts using a case‐parent trio design |
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| Linkage disequilibrium mapping with genotype data |
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| International Genetic Epidemiology Society: Commentary on <i>Darkness in El Dorado</i> by Patrick Tierney |
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| Abstracts from the Tenth Annual Meeting of the International Genetic Epidemiology Society |
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| Tumor necrosis factor‐α promoter variant 2 (<i>TNF2</i>) is associated with pre‐term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort Project IX |
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| Book Review |
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| Is peak height sufficient? |
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| Lod scores for gene mapping in the presence of marker map uncertainty |
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| Association and aggregation analysis using kin‐cohort designs with applications to genotype and family history data from the Washington Ashkenazi Study |
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✓ |
✓ |
Ashkenazi ("Washington Ashkenazi Study") |
| Association studies for quantitative traits in structured populations |
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| Genome‐wide linkage analyses of total serum IgE using variance components analysis in asthmatic families |
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✓ |
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✓ |
✓ |
African‐American; racial groups |
| Power comparisons between the TDT and two likelihood-based methods |
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| Tree‐based recursive partitioning methods for subdividing sibpairs into relatively more homogeneous subgroups |
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| A Bayesian approach to the transmission/disequilibrium test for binary traits |
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| Genome‐wide linkage analysis of blood pressure in Mexican Americans |
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✓ |
✓ |
Mexican Americans |
| Efficient use of siblings in testing for linkage and association |
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| A computationally simple test of homogeneity of odds ratios for twin data |
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| Book Review |
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| Power and robustness of a score test for linkage analysis of quantitative traits using identity by descent data on sib pairs |
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| Evidence for further breast cancer susceptibility genes in addition to <i>BRCA1</i> and <i>BRCA2</i> in a population‐based study |
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| Efficiency of DNA pooling to estimate joint allele frequencies and measure linkage disequilibrium |
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| Multipoint development of the weighted pairwise correlation (WPC) linkage method for pedigrees of arbitrary size and application to the analysis of breast cancer and alcoholism familial data |
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| Author index |
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| A unified framework for transmission‐disequilibrium test analysis of discrete and continuous traits |
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| Cancer risks to spouses and offspring in the family-cancer database |
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| A general and accurate approach for computing the statistical power of the transmission disequilibrium test for complex disease genes |
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| Stoppage: An issue for segregation analysis |
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| Power of multipoint identity‐by‐descent methods to detect linkage using variance component models |
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| Estimation of allele frequencies with data on sibships |
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| Stratified case sampling and the use of family controls |
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| Gibbs sampling–based segregation analysis of asthma‐associated quantitative traits in a population‐based sample of nuclear families |
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✓ |
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| Issues concerning association studies for fine mapping a susceptibility gene for a complex disease |
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| On the validity of the TDT test in the presence of comorbidity and ascertainment bias |
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| Involvement ofBRCA1 andBRCA2 in breast cancer in a western Finnish sub-population |
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✓ |
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western Finnish sub-population |
| True and false positive peaks in genomewide scans: The long and the short of it |
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| Mixture models for linkage analysis of affected sibling pairs and covariates |
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| Influence of genes and family environment on adult smoking behavior assessed in an adoption study |
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| Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseases |
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✓ |
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| Neoplasms in neurofibromatosis 1 are related to gender but not to family history of cancer |
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| Design considerations for association studies of candidate genes in families |
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| Multipoint analysis using affected sib pairs: Incorporating linkage evidence from unlinked regions |
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| Abstracts from the Tenth Annual Meeting of the International Genetic Epidemiology Society |
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| A study comparing precision of the maximum multipoint heterogeneity LOD statistic to three model‐free multipoint linkage methods |
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