| Trade-off between false positives and false negatives in the linkage analysis of complex traits |
|
|
|
|
|
|
|
|
|
| Power of variance component linkage analysis to detect epistasis |
|
|
|
|
|
|
|
|
|
| Identifying genetic markers to assess the presence of gene-environment interactions |
|
|
|
|
|
|
|
|
|
| The effect of selective sampling on mapping quantitative trait loci |
|
|
|
|
|
|
|
|
|
| Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes |
|
|
|
|
|
|
|
|
|
| Sib-pair linkage analyses of nuclear family data: Quantitative versus dichotomous disease classification |
|
|
|
|
|
|
|
|
|
| False positive rates in a genomic screen for complex quantitative traits |
|
|
|
|
|
|
|
|
|
| Genetics of type III hyperlipoproteinemia |
|
|
|
|
|
|
|
|
|
| Exact transmission-disequilibrium tests with multiallelic markers |
|
|
|
|
|
|
|
|
|
| Empirical affected-sib-pair statistics: Two simulation strategies |
|
|
|
|
|
|
|
|
|
| Confidence intervals for relative risk estimates from affected-sib-pair data |
|
|
|
|
|
|
|
|
|
| Association of posterior p-values of S.A.G.E. SIBPAL proportion-IBD and Haseman-Elston statistics for ACTHR112 |
|
|
|
|
|
|
|
|
|
| Parental transmission and D18S37 allele sharing in bipolar affective disorder |
|
|
|
|
|
|
|
|
|
| Impact of adjustments for intermediate phenotypes on the power to detect linkage |
|
|
|
|
|
|
|
|
|
| Analysis of gene-smoking interaction in lung cancer |
|
|
|
|
|
|
|
|
|
| The fifth annual meeting of the International Genetic Epidemiology Society, August 17–18,1996, Rio de Janeiro, Brazil |
|
|
|
|
|
|
|
|
|
| Population–based family study designs: An interdisciplinary research framework for genetic epidemiology |
|
|
|
|
|
|
|
|
|
| Linkage analysis of complex traits using affected sibpairs: Effects of single-locus approximations on estimates of the required sample size |
|
|
|
|
|
|
|
|
|
| Analyzing sibship correlations in birth weight using large sibships from Norway |
|
|
|
|
|
|
|
|
|
| Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18? |
|
|
|
|
|
|
|
|
|
| Incorporation of covariates into genome scanning using sib-pair analysis in bipolar affective disorder |
|
|
|
|
|
|
|
|
|
| Affected-sib-pair analyses of bipolar disorder using data on chromosome 18 |
|
|
|
|
|
|
|
|
|
| A comprehensive analysis of complex traits in problem 2A |
|
|
|
|
|
|
|
|
|
| Linked markers and age at diagnosis |
|
|
|
|
|
|
|
|
|
| Comparison of sib-pair and variance-components methods for genomic screening |
|
|
|
|
|
|
|
|
|
| A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits |
|
|
|
|
|
|
|
|
|
| Apolipoprotein E phenotype, arterial disease, and mortality among older women: The study of osteoporotic fractures |
|
|
|
|
|
|
|
|
|
| Genetic analysis of families with nonsmoking lung cancer probands |
|
|
|
|
|
|
|
|
|
| No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease |
|
|
|
|
|
|
|
|
|
| An extension of affected-pedigree-member analyses to triads of relatives |
|
|
|
|
|
|
|
|
|
| The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data |
|
|
|
|
|
|
|
|
|
| Genomic sharing surrounding alleles identical by descent: Effects of genetic drift and population growth |
|
|
|
|
|
|
|
|
|
| Deriving components of genetic variance for multilocus models |
|
|
|
|
|
|
|
|
|
| Analysis of bipolar disorder using affected relatives |
|
|
|
|
|
|
|
|
|
| Exploring linkage of chromosome 18 markers and bipolar disease |
|
|
|
|
|
|
|
|
|
| Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder |
|
|
|
|
|
|
|
|
|
| A Monte Carlo permutation approach to choosing an affection status model for bipolar affective disorder |
|
|
|
|
|
|
|
|
|
| A multivariate approach to affected-sib-pair analysis using highly dense molecular maps |
|
|
|
|
|
|
|
|
|
| Improvement of the power to detect complex disease genes by regional inference procedures |
|
|
|
|
|
|
|
|
|
| Multilocus quantitative trait analysis using the multipoint identity-by-descent method |
|
|
|
|
|
|
|
|
|
| Multipoint analysis of quantitative traits |
|
|
|
|
|
|
|
|
|
| Genomic scanning and the transmission/disequilibrium test: Analysis of error rates |
|
|
|
|
|
|
|
|
|
| The utility of deviant sib pairs in the detection of linkage |
|
|
|
|
|
|
|
|
|
| Factors influencing the identification of major genes in a complex disease genome scan |
|
|
|
|
|
|
|
|
|
| Major genetic effect on forced vital capacity: The Humboldt family study |
|
|
|
|
|
|
|
|
|
| Affected sibpair linkage tests for multiple linked susceptibility genes |
|
|
|
|
|
|
|
|
|
| Transforming growth factor α locus and nonsyndromic cleft lip with or without cleft palate: A reappraisal |
|
|
|
|
|
|
|
|
|
| MCMC segregation and linkage analysis |
|
|
|
|
|
|
|
|
|
| Linkage analysis of complex disorders with multiple phenotypic categories: Simulation studies and application to bipolar disorder data |
|
|
|
|
|
|
|
|
|
| GENEHUNTER: Application to analysis of bipolar pedigrees and some extensions |
|
|
|
|
|
|
|
|
|
| Modeling the phenotype in parametric linkage analysis of bipolar disorder |
|
|
|
|
|
|
|
|
|
| Probabilistic diagnosis in linkage analysis of bipolar disorder: Putting weights on the fringe |
|
|
|
|
|
|
|
|
|
| False discoveries in genome scanning |
|
|
|
|
|
|
|
|
|
| The “possible triangle” test for extreme discordant sib pairs |
|
|
|
|
|
|
|
|
|
| Detecting linkage for a complex disease using simulated extended pedigrees |
|
|
|
|
|
|
|
|
|
| Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees |
|
|
|
|
|
|
|
|
|
| Testing the utility of mod scores and sib-pair analysis to detect presence of disease susceptibility loci |
|
|
|
|
|
|
|
|
|
| A new statistical test for age-of-onset anticipation: Application to bipolar disorder |
|
|
|
|
|
|
|
|
|
| Description of the Genetic Analysis Workshop 10 bipolar disorder linkage data sets |
|
|
|
|
|
|
|
|
|
| A new test statistic for linkage applied to bipolar disorder and marker D18S41 |
|
|
|
|
|
|
|
|
|
| Comparison of selected methods used to analyze bipolar disorder |
|
|
|
|
|
|
|
|
|
| Genome screening using extremely discordant and extremely concordant sib pairs |
|
|
|
|
|
|
|
|
|
| A population based family study of a common oligogenic disease — part I: Association/aggregation analysis |
|
|
|
|
|
|
|
|
|
| Analysis of complex oligogenic disease |
|
|
|
|
|
|
|
|
|
| The method of sib-pair linkage analysis in context of case-control design |
|
|
|
|
|
|
|
|
|
| Joint segregation and linkage analysis of a quantitative trait compared to separate analyses |
|
|
|
|
|
|
|
|
|
| Genome screening using extremely discordant and extremely concordant sib pairs |
|
|
|
|
|
|
|
|
|
| Detecting linkage for a complex disease using simulated extended pedigrees |
|
|
|
|
|
|
|
|
|
| Exact transmission‐disequilibrium tests with multiallelic markers |
|
|
|
|
|
|
|
|
|
| Variation at the lipoprotein lipase and apolipoprotein AI-CIII gene loci are associated with fasting lipid and lipoprotein traits in a population sample from Iceland: Interaction between genotype, gen |
|
|
|
|
|
|
|
|
|
| Empirical genomewide significance levels established by whole genome simulations |
|
|
|
|
|
|
|
|
|
| An extension of affected‐pedigree‐member analyses to triads of relatives |
|
|
|
|
|
|
|
|
|
| False positive rates in a genomic screen for complex quantitative traits |
|
|
|
|
|
|
|
|
|
| The method of sib‐pair linkage analysis in context of case‐control design |
|
|
|
|
|
|
|
|
|
| Gender-specific nonrandom association between the α1-antichymotrypsin and apolipoprotein E polymorphisms in the general population and its implication for the risk of Alzheimer's disease |
|
|
|
|
|
|
|
|
|
| Analysis of bipolar disorder using affected relatives |
|
|
|
|
|
|
|
|
|
| Comparison of selected methods used to analyze bipolar disorder |
|
|
|
|
|
|
|
|
|
| Improvement of the power to detect complex disease genes by regional inference procedures |
|
|
|
|
|
|
|
|
|
| A comprehensive analysis of complex traits in problem 2A |
|
|
|
|
|
|
|
|
|
| The “possible triangle” test for extreme discordant sib pairs |
|
|
|
|
|
|
|
|
|
| Genetic analysis of families with nonsmoking lung cancer probands |
|
|
|
|
|
|
|
|
|
| Transforming growth factor α locus and nonsyndromic cleft lip with or without cleft palate: A reappraisal |
|
|
|
|
|
|
|
|
|
| MCMC segregation and linkage analysis |
|
|
|
|
|
|
|
|
|
| Empirical affected‐sib‐pair statistics: Two simulation strategies |
|
|
|
|
|
|
|
|
|
| Genotype relative-risks and association tests for nuclear families with missing parental data |
|
|
|
|
|
|
|
|
|
| Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18? |
|
|
|
|
|
|
|
|
|
| Association of posterior p‐values of S.A.G.E. SIBPAL proportion‐IBD and Haseman‐Elston statistics for ACTHR112 |
|
|
|
|
|
|
|
|
|
| A new test statistic for linkage applied to bipolar disorder and marker D18S41 |
|
|
|
|
|
|
|
|
|
| Affected sib-pair tests for linkage: Type I errors with dependent sib-pairs |
|
|
|
|
|
|
|
|
|
| Linkage analysis of complex disorders with multiple phenotypic categories: Simulation studies and application to bipolar disorder data |
|
|
|
|
|
|
|
|
|
| Prior segregation analysis and the power to detect linkage |
|
|
|
|
|
|
|
|
|
| Multilocus quantitative trait analysis using the multipoint identity‐by‐descent method |
|
|
|
|
|
|
|
|
|
| Alternative test for linkage between two loci |
|
|
|
|
|
|
|
|
|
| Genetic analysis with hierarchical models |
|
|
|
|
|
|
|
|
|
| Investigation of the candidate genes ACTHR and Golf for bipolar illness by the transmission/disequilibrium test |
|
|
|
|
|
|
|
|
|
| Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes |
|
|
|
|
|
|
|
|
|
| The effect of selective sampling on mapping quantitative trait loci |
|
|
|
|
|
|
|
|
|
| Exploiting pleiotropy to map genes for oligogenic phenotypes using extended pedigree data |
|
|
|
|
|
|
|
|
|
| Regressive logistic modeling of familial aggregation for asthma in 7,394 population-based nuclear families |
|
|
|
|
|
|
|
|
|
| Self-contained subsets method for estimation of gene frequencies of truncated genetic data |
|
|
|
|
|
|
|
|
|
| Paternal age and sporadic neurofibromatosis 1: A case-control study and consideration of the methodologic issues |
|
|
|
|
|
|
|
|
|
| Bipolar disorder and chromosome 18: An analysis of multiple data sets |
|
|
|
|
|
|
|
|
|
| Empirical evaluation of genome scans for linkage of a quantitative trait associated with a complex disorder |
|
|
|
|
|
|
|
|
|
| Detecting gene-environment interactions using a case-control design |
|
|
|
|
|
|
|
|
|
| A meta-analysis of chromosome 18 linkage data for bipolar illness |
|
|
|
|
|
|
|
|
|
| GAW10: Simulated family data for a common oligogenic disease with quantitative risk factors |
|
|
|
|
|
|
|
|
|
| A Bayesian approach to multipoint mapping in nuclear families |
|
|
|
|
|
|
|
|
|
| Multipoint oligogenic linkage analysis of quantitative traits |
|
|
|
|
|
|
|
|
|
| Genetics of type III hyperlipoproteinemia |
|
|
|
|
|
|
|
|
|
| Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages |
|
|
|
|
|
|
|
|
|
| Trends and patterns of mortality associated with birth defects and genetic diseases in the United States, 1979–1992: An analysis of multiple-cause mortality data |
|
|
|
|
|
|
|
|
|
| Sequential sib-pair and association studies to detect genes in quantitative traits |
|
|
|
|
|
|
|
|
|
| WPC test based on randomization for analyzing quantitative traits on simulated pedigrees |
|
|
|
|
|
|
|
|
|
| Probabilities of identity-by-descent patterns in sibships when the parents are not genotyped |
|
|
|
|
|
|
|
|
|
| Down's syndrome and maternal smoking in early pregnancy |
|
|
|
|
|
|
|
|
|
| Sample size required for predefined linkage decision quality |
|
|
|
|
|
|
|
|
|
| Identifying genetic markers to assess the presence of gene‐environment interactions |
|
|
|
|
|
|
|
|
|
| Affected‐sib‐pair analyses of bipolar disorder using data on chromosome 18 |
|
|
|
|
|
|
|
|
|
| Major genetic effect on forced vital capacity: The Humboldt family study |
|
|
|
|
|
|
|
|
|
| Detection and replication of linkage to a complex human disease |
|
|
|
|
|
|
|
|
|
| Modeling the phenotype in parametric linkage analysis of bipolar disorder |
|
|
|
|
|
|
|
|
|
| Logistic transmission modeling for the simulated data of GAW10 problem 2 |
|
|
|
|
|
|
|
|
|
| Analysis of gene‐smoking interaction in lung cancer |
|
|
|
|
|
|
|
|
|
| No association or linkage between an intronic polymorphism of presenilin‐1 and sporadic or late‐onset familial Alzheimer disease |
|
|
|
|
|
|
|
|
|
| Trade‐off between false positives and false negatives in the linkage analysis of complex traits |
|
|
|
|
|
|
|
|
|
| Power of variance component linkage analysis to detect epistasis |
|
|
|
|
|
|
|
|
|
| Impact of adjustments for intermediate phenotypes on the power to detect linkage |
|
|
|
|
|
|
|
|
|
| A multivariate approach to affected‐sib‐pair analysis using highly dense molecular maps |
|
|
|
|
|
|
|
|
|
| A population based family study of a common oligogenic disease — part I: Association/aggregation analysis |
|
|
|
|
|
|
|
|
|
| Sib‐pair linkage analyses of nuclear family data: Quantitative versus dichotomous disease classification |
|
|
|
|
|
|
|
|
|
| Analysis of complex oligogenic disease |
|
|
|
|
|
|
|
|
|
| Joint segregation and linkage analysis of a quantitative trait compared to separate analyses |
|
|
|
|
|
|
|
|
|
| Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees |
|
|
|
|
|
|
|
|
|
| Computation of multilocus prior probability of autozygosity for complex inbred pedigrees |
|
|
|
|
|
|
|
|
|
| Comparison of methods for analyzing binary data arising from two-sample twin studies |
|
|
|
|
|
|
|
|
|
| Genetic analysis of bipolar disorder: Summary of GAW10 |
|
|
|
|
|
|
|
|
|
| Comparison of evidence for linkage from different analytic methods |
|
|
|
|
|
|
|
|
|
| Segregation analysis of cardiovascular reactivity to laboratory stressors |
|
|
|
|
|
|
|
|
|
| Evaluation of potential sources of bias in a genetic epidemiologic study of breast cancer |
|
|
|
|
|
|
|
|
|
| Effects of genotype-by-sex interaction on quantitative trait linkage analysis |
|
|
|
|
|
|
|
|
|
| The power of iterated generalized least squares (GLS) method to detect direct relationships in the analysis of correlated quantitative traits |
|
|
|
|
|
|
|
|
|
| Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: Extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity |
|
|
|
|
|
|
|
|
|
| No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples |
|
|
|
|
|
|
|
|
|
| Caution in the interpretation of MLS |
|
|
|
|
|
|
|
|
|
| A population-based family study (II): Segregation analysis |
|
|
|
|
|
|
|
|
|
| Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate |
|
|
|
|
|
|
|
|
|
| Affected-only multiplex pedigree analysis of GAW10 problem 2 |
|
|
|
|
|
|
|
|
|
| Serum distribution of lipoprotein(a) in African Americans and Nigerians: Potential evidence for a genotype-environmental effect |
|
|
|
|
|
|
|
|
|
| Disease classification and transmission effects on linkage analyses in the NIMH1 bipolar disorder pedigrees |
|
|
|
|
|
|
|
|
|
| Abstracts from the Sixth Annual Meeting of the International Genetic Epidemiology Society, Baltimore, Maryland, October 27–28,1997 |
|
|
|
|
|
|
|
|
|
| Heritability of factors of the insulin resistance syndrome in women twins |
|
|
|
|
|
|
|
|
|
| Heritability of plasma leptin in a population sample of African-American families |
|
|
|
|
|
|
✓ |
|
African-American |
| Synergistic effect of two HLA heterodimers in the susceptibility to celiac disease in Tunisia |
|
|
|
|
|
|
|
|
|
| The fifth annual meeting of the International Genetic Epidemiology Society, August 17–18, 1996, Rio de Janeiro, Brazil |
|
|
|
|
|
|
|
|
|
| Prevalence of factor V Leiden mutation in various populations |
|
|
|
|
|
|
|
|
|
| Incorporation of covariates into genome scanning using sib‐pair analysis in bipolar affective disorder |
|
|
|
|
|
|
|
|
|
| A Monte Carlo permutation approach to choosing an affection status model for bipolar affective disorder |
|
|
|
|
|
|
|
|
|
| Linked markers and age at diagnosis |
|
|
|
|
|
|
|
|
|
| Comparison of sib‐pair and variance‐components methods for genomic screening |
|
|
|
|
|
|
|
|
|
| The utility of deviant sib pairs in the detection of linkage |
|
|
|
|
|
|
|
|
|
| Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci |
|
|
|
|
|
|
|
|
|
| Apolipoprotein E phenotype, arterial disease, and mortality among older women: The study of osteoporotic fractures |
|
|
|
|
|
|
|
|
|
| Population–based family study designs: An interdisciplinary research framework for genetic epidemiology |
|
|
|
|
|
|
|
|
|
| Genomic sharing surrounding alleles identical by descent: Effects of genetic drift and population growth |
|
|
|
|
|
|
|
|
|
| Deriving components of genetic variance for multilocus models |
|
|
|
|
|
|
|
|
|
| Description of the Genetic Analysis Workshop 10 bipolar disorder linkage data sets |
|
|
|
|
|
|
|
|
|
| Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder |
|
|
|
|
|
|
|
|
|
| Probabilistic diagnosis in linkage analysis of bipolar disorder: Putting weights on the fringe |
|
|
|
|
|
|
|
|
|
| Multipoint analysis of quantitative traits |
|
|
|
|
|
|
|
|
|
| A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits |
|
|
|
|
|
|
|
|
|
| Factors influencing the identification of major genes in a complex disease genome scan |
|
|
|
|
|
|
|
|
|
| The performance of MIM in comparison with MAPMAKER/SIBS to detect QTLs |
|
|
|
|
|
|
|
|
|
| Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: Summary of GAW10 contributions |
|
|
|
|
|
|
|
|
|
| Comparison of model-free linkage mapping strategies for the study of a complex trait |
|
|
|
|
|
|
|
|
|
| Segregation analysis of fat mass and fat-free mass with age- and sex-dependent effects: The Stanislas family study |
|
|
|
|
|
|
|
|
|
| Model-free age-of-onset methods applied to the linkage of bipolar disorder |
|
|
|
|
|
|
|
|
|
| Genomic scanning and the transmission/disequilibrium test: Analysis of error rates |
|
|
|
|
|
|
|
|
|
| Analysis of two-locus traits under heterogeneity for recessive versus dominant inheritance |
|
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| Parental sex effects in bipolar affective disorder pedigrees |
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| Heterogeneity of marker allele frequencies hinders interpretation of linkage analysis: Illustration on chromosome 18 markers |
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| Use of computer simulation to evaluate a putative cluster of genetic or teratologic outcomes: Adjustment for “multiple hypotheses” and application to a reported excess of Down's syndrome |
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| Evidence against genetic anticipation in familial colorectal cancer |
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| Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees |
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| Affected sibpair linkage tests for multiple linked susceptibility genes |
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| Linkage analysis of complex traits using affected sibpairs: Effects of single‐locus approximations on estimates of the required sample size |
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| Analyzing sibship correlations in birth weight using large sibships from Norway |
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| Testing the utility of mod scores and sib‐pair analysis to detect presence of disease susceptibility loci |
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| A new statistical test for age‐of‐onset anticipation: Application to bipolar disorder |
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| Confidence intervals for relative risk estimates from affected‐sib‐pair data |
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| Exploring linkage of chromosome 18 markers and bipolar disease |
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| Covariate effects on linkage and association using a general pair method |
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| The role of smoothing techniques in the interpretation of results from genomic scans using sib‐pair data |
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| Neural network analysis of complex traits |
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| Bipolar disorder: Dominant or recessive on chromosome 5? |
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| Haplotype sharing analysis in affected individuals from nuclear families with at least one affected offspring |
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| A variance component approach to dichotomous trait linkage analysis using a threshold model |
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| GENEHUNTER: Application to analysis of bipolar pedigrees and some extensions |
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| False discoveries in genome scanning |
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| Investigating the numerical effects of ascertainment bias in linkage analysis: Development of methods and preliminary results |
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| Genetic factors in the aetiology of mouth ulcers |
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| Parental transmission and D18S37 allele sharing in bipolar affective disorder |
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