| Polymorphisms in <i>CRHR1</i> and the serotonin transporter loci: Gene × Gene × Environment interactions on depressive symptoms |
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| Association study of <i>NRG1</i>, <i>DTNBP1</i>, <i>RGS4</i>, <i>G72</i>/<i>G30</i>, and <i>PIP5K2A</i> with schizophrenia and symptom severity in a Hungarian sample |
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✓ |
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✓ |
✓ |
Hungarian |
| Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study |
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| Psychiatric syndromes in individuals with chromosome 18 abnormalities |
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| Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers |
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| Association study of bromodomain‐containing 1 gene with schizophrenia in Japanese population |
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✓ |
✓ |
Scottish population; Japanese population |
| Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample |
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| Association between polymorphisms in the metallophosphoesterase (<i>MPPE1</i>) gene and bipolar disorder |
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| Association and interaction analysis of variants in <i>CHRNA5/CHRNA3/CHRNB4</i> gene cluster with nicotine dependence in African and European Americans |
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✓ |
✓ |
✓ |
✓ |
European Americans (EAs); others of European origin; African Americans (AAs); references to 'ethnic populations' and 'ethnic samples' |
| Mutation screening of the <i>DTNBP1</i> exonic sequence in 669 schizophrenics and 710 controls using high‐resolution melting analysis |
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| Quantitative analysis of alternative transcripts of human <i>PCDH11X/Y</i> genes |
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| Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population |
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✓ |
✓ |
Finnish; Finnish families; Finnish population; North-Eastern region of Finland; late settlement regi |
| Association of the SAT1 in/del polymorphism with suicide completion |
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✓ |
✓ |
French-Canadian |
| Relevance of perceived childhood neglect, 5‐HTT gene variants and hypothalamus–pituitary–adrenal axis dysregulation to substance abuse susceptibility |
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| Promoter variants of the cannabinoid receptor 1 gene (CNR1) in interaction with <i>5‐HTTLPR</i> affect the anxious phenotype |
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| Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene–environment interplay |
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| Suggestive evidence for linkage of ADHD features in bipolar disorder to chromosome 10p14 |
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| Family‐based association study of Neuregulin 1 with psychotic bipolar disorder |
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✓ |
✓ |
Icelandic |
| Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: Suggestive linkage to 3q13 |
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| <i>Stathmin</i>, a gene regulating neural plasticity, affects fear and anxiety processing in humans |
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| <i>Parkin</i> gene modifies the effect of <i>RLS4</i> on the age at onset of restless legs syndrome (RLS) |
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✓ |
✓ |
South Tyrolean |
| The role of the COMT Val<sup>158</sup>Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder |
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| Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive‐compulsive disorder |
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| Genetic linkage of region containing the<i>CREB1</i>gene to depressive disorders in families with recurrent, early‐onset, major depression: A re‐analysis and confirmation of sex‐specific effect |
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| An association between Epac‐1 gene variants and anxiety and depression in two independent samples |
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✓ |
✓ |
Dutch; USA |
| Non‐replication of association for six polymorphisms from meta‐analysis of genome‐wide association studies of Parkinson's disease: Large‐scale collaborative study |
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| Genetic analysis of Parkin in early onset Parkinson's disease (PD): Novel intron 9 g > a single nucleotide polymorphism and risk of Taiwanese PD |
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| Evidence for epistasis between <i>SLC6A4</i> and a chromosome 4 gene as risk factors in major depression |
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| A candidate gene study of tardive dyskinesia in the CATIE schizophrenia trial |
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| Association analysis of the <i>PIP4K2A</i> gene on chromosome 10p12 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF) and the Irish case–control study of schizophren |
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✓ |
✓ |
Irish; Irish population; Irish Study of High Density Schizophrenia Families (ISHDSF); Irish case–con |
| No evidence of an association between two genes, <i>EDN1</i> and <i>ACE</i>, and childhood‐onset mood disorders |
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| Novel extreme homozygote haplotypes at the human caveolin 1 gene upstream purine complex in sporadic Alzheimer's disease |
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| Pharmacogenetics of smoking cessation therapy |
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| Functional characterization of three single‐nucleotide polymorphisms present in the human <i>APOE</i> promoter sequence: Differential effects in neuronal cells and on DNA–protein interactions |
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| Sexually dimorphic effect of the Val66Met polymorphism of <i>BDNF</i> on susceptibility to Alzheimer's disease: New data and meta‐analysis |
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| Unstable familial transmissions of Huntington disease alleles with 27–35 CAG repeats (intermediate alleles) |
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| Association study of the serotoninergic system in migraine in the spanish population |
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✓ |
✓ |
Spanish population |
| Epileptic encephalopathy in a girl with an interstitial deletion of Xp22 comprising promoter and exon 1 of the <i>CDKL5</i> gene |
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| Nucleotide variation in central nervous system genes among male suicide attempters |
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| A sequencing‐based survey of functional <i>APAF1</i> alleles in a large sample of individuals with affective illness and population controls |
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✓ |
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northern European and European‐American subjects; Northern European and European‐American population |
| Promoter polymorphisms which modulate <i>BACE1</i> expression are associated with sporadic Alzheimer's disease |
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✓ |
✓ |
Han Chinese descent |
| An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder |
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| Familiality and molecular genetics of attention networks in ADHD |
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| Linear clinical progression, independent of age of onset, in Niemann–Pick disease, type C |
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| <i>TRPM7</i> is not associated with amyotrophic lateral sclerosis‐parkinsonism dementia complex in the Kii peninsula of Japan |
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| Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder |
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✓ |
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| BDNF, relative preference, and reward circuitry responses to emotional communication |
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| ADHD and DAT1: Further evidence of paternal over‐transmission of risk alleles and haplotype |
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| Autistic traits in simplex and multiplex autism families: Focus on unaffected relatives |
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| Gender‐specific<i>COMT</i>Val158Met polymorphism association in Spanish schizophrenic patients |
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✓ |
✓ |
Spanish |
| Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population |
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✓ |
✓ |
Southern Chinese |
| A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis |
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| <i>NRG1</i> gene in recurrent major depression: No association in a large‐scale case–control association study |
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✓ |
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✓ |
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White European ancestry |
| Association study of <i>PDE4B</i> gene variants in scandinavian schizophrenia and bipolar disorder multicenter case–control samples |
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✓ |
✓ |
Scandinavian |
| Heritability of age of onset of psychosis in schizophrenia |
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| Functional polymorphisms in the serotonin 1B receptor gene (<i>HTR1B</i>) predict self‐reported anger and hostility among young men |
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| The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: A meta‐analysis |
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✓ |
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European (compared with Asian) ancestry |
| The multidimensionality of schizotypy in nonpsychotic relatives of patients with schizophrenia and its applications in ordered subsets linkage analysis of schizophrenia |
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| Variation in <i>P2RX7</i> candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples |
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✓ |
✓ |
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"four European samples"; "four European bipolar I disorder samples from Germany, Poland, Romania, an |
| Positive association between the brain‐derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population |
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| Risk variants in the S100B gene predict elevated S100B serum concentrations in healthy individuals |
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| A narrow and highly significant linkage signal for severe bipolar disorder in the chromosome 5q33 region in Latin American pedigrees |
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| Screening for copy number alterations in loci associated with autism spectrum disorders by two‐color multiplex ligation‐dependent probe amplification |
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| Linkage disequilibrium mapping of the chromosome 6q21–22.31 bipolar I disorder susceptibility locus |
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| Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium |
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| A broad spectrum of developmental delay in a large cohort of prolidase deficiency patients demonstrates marked interfamilial and intrafamilial phenotypic variability |
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| COMT val158met influence on electroconvulsive therapy response in major depression |
|
✓ |
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| An association study of common variation at the <i>MAPT</i> locus with late‐onset Alzheimer's disease |
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| A linkage search for joint panic disorder/bipolar genes |
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| Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (<i>CHRN</i>) genes |
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✓ |
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European descent |
| Suggestive linkage at 9p22 in bipolar disorder weighted by alcohol abuse |
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| Association of the α4 integrin subunit gene (<i>ITGA4</i>) with autism |
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| Preliminary genome‐wide association study of bipolar disorder in the Japanese population |
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| Convergent genome wide association results for bipolar disorder and substance dependence |
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| Evidence that self‐reported psychotic experiences represent the transitory developmental expression of genetic liability to psychosis in the general population |
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| Polymorphisms in the GAD2 gene‐region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders |
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| The role of the brain‐derived neurotrophic factor (<i>BDNF</i>) <i>val66met</i> variant in the phenotypic expression of obsessive‐compulsive disorder (OCD) |
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| Genetic association studies of methamphetamine use disorders: A systematic review and synthesis |
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| Regionally reduced brain volume, altered serotonin neurochemistry, and abnormal behavior in mice null for the circadian rhythm output gene <i>Magel2</i> |
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| A twin concordance study of trichotillomania |
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| Variants of the serotonin transporter gene and NEO‐PI‐R Neuroticism: No association in the BLSA and SardiNIA samples |
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| <i>SPG11</i> mutations cause Kjellin syndrome, a hereditary spastic paraplegia with thin corpus callosum and central retinal degeneration |
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| Association study of CREB1 with Major Depressive Disorder and related phenotypes |
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| Common and rare variants of <i>DAOA</i> in bipolar disorder |
|
✓ |
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| No association between two polymorphisms of the serotonin transporter gene and combined type attention deficit hyperactivity disorder |
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| Association studies and gene expression analyses of the DISC1‐interacting molecules, pericentrin 2 (<i>PCNT2</i>) and DISC1‐binding zinc finger protein (<i>DBZ</i>), with schizophrenia and with bipola |
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✓ |
✓ |
Japanese |
| Heritability of neurocognitive traits in familial schizophrenia |
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| Genetic linkage findings for DSM‐IV nicotine withdrawal in two populations |
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✓ |
✓ |
Australian, Finnish (AUS, FIN) |
| Family‐based association of <i>YWHAH</i> in psychotic bipolar disorder |
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| Homozygosity mapping through whole genome analysis identifies a <i>COL18A1</i> mutation in an Indian family presenting with an autosomal recessive neurological disorder |
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| <i>P2RX7</i>: A bipolar and unipolar disorder candidate susceptibility gene? |
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| Genetic variation in 5HTTLPR is associated with emotional resilience |
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✓ |
✓ |
ancestry proportion scores (to mitigate confounding by population stratification) |
| LRRK2 G2385R modulates age at onset in Parkinson's disease: A multi‐center pooled analysis |
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| Evidence for an interaction of schizophrenia susceptibility loci on chromosome 6q23.3 and 10q24.33–q26.13 in Arab Israeli families |
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✓ |
✓ |
Arab Israeli families |
| Profiling brain expression of the spermidine/spermine <i>N</i><sup>1</sup>‐acetyltransferase 1 (SAT1) gene in suicide |
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✓ |
✓ |
French‐Canadian origin; German subjects; French‐Canadian origin; German subjects |
| Consanguinity associated with increased risk for bipolar I disorder in Egypt |
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| A family‐based association study of the glutamate transporter gene <i>SLC1A1</i> in obsessive–compulsive disorder in 378 families |
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| Evidence that putative ADHD low risk alleles at<i>SNAP25</i>may increase the risk of schizophrenia |
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| Variants in nicotinic acetylcholine receptors α5 and α3 increase risks to nicotine dependence |
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| Gender moderates the relationship between mania spectrum and serotonin transporter polymorphisms in depression |
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| Association of the dystrobrevin binding protein 1 gene (<i>DTNBP1</i>) in a bipolar case–control study (BACCS) |
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| Mutation screen and association analysis of the glucocorticoid receptor gene (<i>NR3C1</i>) in childhood‐onset mood disorders (COMD) |
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✓ |
✓ |
Hungarian |
| Impact of the dopamine receptor gene family on temperament traits in a population‐based birth cohort |
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✓ |
✓ |
Finnish population‐based birth cohort; references to 'population' and 'genetic homogeneity and genea |
| An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in <i>ACE</i> and putative multilocus association between <i>ACE</i>, <i>A2M</i>, and <i>LRRTM3</ |
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✓ |
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| The <i>FMR1</i> gene and fragile X‐associated tremor/ataxia syndrome |
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| Association of reduced folate carrier gene polymorphism and maternal folic acid use with neural tube defects |
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| Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non‐synonymous SNPs of 306 genes involved in neurotransmission and neuro |
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| Characterization of a de novo translocation t(5;18)(q33.1;q12.1) in an autistic boy identifies a breakpoint close to<i>SH3TC2</i>,<i>ADRB2</i>, and<i>HTR4</i>on 5q, and within the desmocollin gene clu |
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| Linkage analysis of schizophrenia controlling for population substructure |
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| Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene–environment interaction |
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| Association of <i>AKT1</i> with verbal learning, verbal memory, and regional cortical gray matter density in twins |
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✓ |
✓ |
Finnish |
| <i>Sapap3</i> and pathological grooming in humans: Results from the OCD collaborative genetics study |
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| Peripheral gene expression profiling of CCK‐4‐induced panic in healthy subjects |
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| Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior |
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| Allelic variants in HTR3C show association with autism |
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✓ |
✓ |
Finnish families |
| Genome scan in sibling pairs with juvenile‐onset mood disorders: Evidence for linkage to 13q and Xq |
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| Evidence supporting a role for the calcium‐sensing receptor in Alzheimer disease |
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| Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence |
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| Tagging SNP association study of the IL‐1β gene (<i>IL1B</i>) and childhood‐onset mood disorders |
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| An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population |
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✓ |
✓ |
Finnish population; originating from Finland |
| Effects of stressful life events, maternal depression and 5‐HTTLPR genotype on emotional symptoms in pre‐adolescent children |
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| Genome‐widely significant evidence of linkage of schizophrenia to chromosomes 2p24.3 and 6q27 in an SNP‐Based analysis of Korean families |
|
✓ |
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| Focus on HTR2C: A possible suggestion for genetic studies of complex disorders |
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