| No association of the GABA<sub>A</sub> receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample |
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| Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study |
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| Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment |
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| Association study between brain‐derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan |
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✓ |
✓ |
Japanese |
| Meta‐analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders |
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| Fine mapping of a region on chromosome 8p gives evidence for a QTL contributing to individual differences in an anxiety‐related personality trait: TPQ harm avoidance |
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| Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: <i>DRD4, DAT1, DRD5, SNAP‐25</i>, and <i>5HT1B</i> |
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| The 3111T/C polymorphism of <i>hClock</i> is associated with evening preference and delayed sleep timing in a Japanese population sample |
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✓ |
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✓ |
✓ |
Japanese population sample |
| Dopamine receptor D4 (<i>DRD4</i>) gene in Han Chinese children with attention‐deficit/hyperactivity disorder (ADHD): Increased prevalence of the 2‐repeat allele |
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✓ |
✓ |
✓ |
European-ancestry; Han Chinese; Asians; ethnically-matched controls |
| Serotonin 5‐HT1B receptor gene and attention deficit hyperactivity disorder in Chinese Han subjects |
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✓ |
✓ |
Chinese Han population |
| No association of a non‐synonymous <i>PLAU</i> polymorphism with Alzheimer's disease and disease‐related traits |
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| Novel exonic μ‐opioid receptor gene (<i>OPRM1</i>) polymorphisms not associated with opioid dependence |
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✓ |
✓ |
✓ |
European‐American (EA) subjects; African‐American (AA) subjects |
| Joint multi‐population analysis for genetic linkage of bipolar disorder or “wellness” to chromosome 4p |
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✓ |
✓ |
Scottish, Danish, and USA (extended pedigrees); references to Scotland, Denmark, USA; 'three populat |
| A genome‐wide search for risk genes using homozygosity mapping and microarrays with 1,494 single‐nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder |
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| New Huntington disease mutation arising from a paternal CAG<sub>34</sub> allele showing somatic length variation in serially passaged lymphoblasts |
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| Relationship between dopaminergic neurotransmission, alcoholism, and reward deficiency syndrome |
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| Molecular genetic studies of ADHD: 1991 to 2004 |
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| Identification of a novel 45 repeat unstable allele associated with a disease phenotype at the MJD1/SCA3 locus |
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✓ |
✓ |
Indian pedigree |
| Relationship of MAO‐A promoter (u‐VNTR) and COMT (V158M) gene polymorphisms to CSF monoamine metabolites levels in a psychiatric sample of caucasians: A preliminary report |
✓ |
✓ |
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| Mutation screen of the brain derived neurotrophic factor gene (<i>BDNF</i>): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attentio |
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| Multiple marker analysis at the promoter region of the <i>DRD4</i> gene and ADHD: Evidence of linkage and association with the SNP −616 |
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✓ |
✓ |
other ethnic groups |
| Linkage disequilibrium mapping of bipolar affective disorder at 12q23‐q24 provides evidence for association at <i>CUX2</i> and <i>FLJ32356</i> |
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✓ |
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| Association analysis of <i>NOTCH 4</i> polymorphisms with schizophrenia among two independent family based samples |
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| Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood‐onset mood disorders |
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| Association of the −141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics |
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of German descent |
| APOE and other loci affect age‐at‐onset in Alzheimer's disease families with PS2 mutation |
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✓ |
✓ |
Volga German (VG) ancestry |
| DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families |
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✓ |
✓ |
Dutch population |
| A genome scan of neuroticism in nicotine dependent smokers |
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| Brain perfusion and dopaminergic genes in boys with attention‐deficit/hyperactivity disorder |
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| MCP‐1 gene (<i>SCYA2</i>) and schizophrenia: A case‐control association study |
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| Genetic variants implicated in personality: A review of the more promising candidates |
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| Phenotype studies of the <i>DRD4</i> gene polymorphisms in ADHD: Association with oppositional defiant disorder and positive family history |
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| Chromosome 19p13 loci in Finnish migraine with aura families |
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✓ |
✓ |
Finnish |
| Neither single‐marker nor haplotype analyses support an association between genetic variation near NOTCH4 and bipolar disorder |
|
✓ |
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| Association study of brain‐derived neurotrophic factor in adults with a history of childhood onset mood disorder |
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| Linkage analyses of four regions previously implicated in dyslexia: Confirmation of a locus on chromosome 15q |
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| CAG repeat polymorphism within the <i>KCNN3</i> gene is a significant contributor to susceptibility to anorexia nervosa: A case‐control study of female patients and several ethnic groups in the Israel |
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✓ |
✓ |
Israeli Jewish population; Jewish ethnic groups of Ashkenazi, North African, Iraqi, and Yemenite ori |
| A linkage disequilibrium map of the 1‐Mb 15q12 GABA<sub>A</sub> receptor subunit cluster and association to autism |
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| Abstracts for the XIIth World Congress of Psychiatric Genetics |
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| Family‐based association study between autism and glutamate receptor 6 gene in Chinese Han trios |
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✓ |
✓ |
Chinese Han |
| Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population |
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✓ |
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✓ |
✓ |
Ashkenazi Jewish; Jewish |
| Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms |
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| Invitation to the XIIth World Congress on Psychiatric Genetics, 9th–13th October 2004, Dublin, Ireland |
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| Genome‐wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early‐onset, major depression |
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| Investigation of the human serotonin receptor gene<i>HTR3B</i>in bipolar affective and schizophrenic patients |
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| Mapping genes of complex psychiatric diseases in Daghestan genetic isolates |
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✓ |
✓ |
Caucasus ethnicities; ethnic groups; indigenous isolates |
| Allelic and haplotypic association of <i>GABRA2</i> with alcohol dependence |
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✓ |
|
|
European American |
| Association between the neurofibromatosis‐1 (NF1) locus and autism in the Japanese population |
|
✓ |
|
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✓ |
✓ |
Caucasians of French ancestry; Japanese subjects |
| <i>NLGN3/NLGN4</i> gene mutations are not responsible for autism in the Quebec population |
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| Positive association of the human frizzled 3 (<i>FZD3</i>) gene haplotype with schizophrenia in Chinese Han population |
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| Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive‐compulsive disorder |
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| Regulator of G‐protein signaling 4 (<i>RGS4</i>) gene is associated with schizophrenia in Irish high density families |
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✓ |
✓ |
Irish |
| Familial symptom domains in monozygotic siblings with autism |
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| Variants of the <i>orexin2</i>/<i>hcrt2</i> receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity |
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| Genomic screen for loci associated with alcohol dependence in Mission Indians |
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| Using nonword repetition to distinguish genetic and environmental influences on early literacy development: A study of 6‐year‐old twins |
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| The dysbindin gene in major depression: An association study |
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| Association of the dopamine transporter gene (<i>DAT1</i>) core promoter polymorphism −67T variant with schizophrenia |
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✓ |
✓ |
ethnicity; Iranian male population |
| Mutation screening of X‐chromosomal neuroligin genes: No mutations in 196 autism probands |
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| Association study of the <i>Epac</i> gene and tobacco smoking and nicotine dependence |
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| Assessment of the frequency of the 22q11 deletion in Afrikaner schizophrenic patients |
|
✓ |
|
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|
|
✓ |
✓ |
Afrikaner origin |
| Do aggressive and non‐aggressive antisocial behaviors in adolescents result from the same genetic and environmental effects? |
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| Forms of cannabis and cocaine: A twin study |
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|
|
| Evidence for association between novel polymorphisms in the <i>PRODH</i> gene and schizophrenia in a Chinese population |
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|
|
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|
|
✓ |
✓ |
Chinese population; Sichuan, SW China |
| A missense polymorphism (S205L) of the low‐affinity neurotrophin receptor <i>p75<sup>NTR</sup></i> gene is associated with depressive disorder and attempted suicide |
|
|
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|
|
✓ |
✓ |
Japanese |
| Lack of relationship between CO<sub>2</sub> reactivity and serotonin transporter gene regulatory region polymorphism in panic disorder |
|
|
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|
|
| <i>ProtocadherinX</i>/<i>Y</i>, a candidate gene‐pair for schizophrenia and schizoaffective disorder: A DHPLC investigation of genomic sequence |
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|
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| New GABA<sub>A</sub> receptor alpha5 subunit gene polymorphism that may confound genotyping |
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|
|
| Lack of association between 5HT<sub>2A</sub> receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample |
|
|
|
|
✓ |
✓ |
|
|
West European sample |
| Non‐replication of the brain‐derived neurotrophic factor (BDNF) association in bipolar affective disorder: A Belgian patient‐control study |
|
|
|
|
|
|
✓ |
✓ |
Belgian origin (at least two generations of Belgian ancestors) |
| Comments on “Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐Americans” |
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|
|
|
✓ |
|
|
|
European‐Americans |
| Family‐based and case‐control association studies of DRD4 and DAT1 polymorphisms in Chinese attention deficit hyperactivity disorder patients suggest long repeats contribute to genetic risk for the di |
|
|
|
|
|
|
✓ |
✓ |
Han Chinese |
| Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders |
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|
|
| Variations in the NMDA receptor subunit 2B gene (<i>GRIN2B</i>) and schizophrenia: A case‐control study |
|
|
|
|
|
|
✓ |
✓ |
Italian |
| No association between DUP25 and anxiety disorders |
|
|
|
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|
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|
|
| Linkage disequlibrium in the <i>DTNBP1</i> (<i>dysbindin</i>) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: Findings from identity by descent haplotype |
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|
|
| Mitochondrial DNA polymorphisms and extraversion |
|
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|
|
✓ |
✓ |
Japanese |
| MECP2 structural and 3′‐UTR variants in schizophrenia, autism and other psychiatric diseases: A possible association with autism |
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|
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|
|
✓ |
✓ |
ethnically similar individuals |
| Association analysis of the <i>DRD4</i> and <i>COMT</i> genes in methamphetamine abuse |
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|
|
| Genetic disorders affecting white matter in the pediatric age |
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| Linkage of eye movement dysfunction to chromosome 6p in schizophrenia: Additional evidence |
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|
| Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1‐15.3 region associated with reading disability |
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|
|
| Dermatoglyphic profile in 22q deletion syndrome |
|
✓ |
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|
|
| Are phonological processing deficits part of the broad autism phenotype? |
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|
|
| Expanded RED products and loci containing CAG/CTG repeats on chromosome 17 (ERDA1) and chromosome 18 (CTG18.1) in trans‐generational pairs with bipolar affective disorder |
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|
|
| NR4A2 and schizophrenia: Lack of association in a Portuguese/Brazilian study |
|
✓ |
|
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|
✓ |
✓ |
Portuguese and Brazilian (as in 'Caucasian Portuguese' and 'Caucasian Brazilian') |
| Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking |
|
|
|
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|
|
✓ |
✓ |
Icelandic |
| <i>COMT</i>: A common susceptibility gene in bipolar disorder and schizophrenia |
|
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|
|
| Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5‐HT1Dα and 5‐HT1Dβ autoreceptor genes: Family‐based association study |
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|
|
Portuguese population |
| Tourette syndrome is not caused by mutations in the central cannabinoid receptor (<i>CNR1</i>) gene |
|
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|
|
| Serotonin 1B (5HT‐1B) receptor polymorphism (G861C) in suicide victims: Association studies in German and Slavic population |
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|
|
✓ |
✓ |
German; Slavic/Croatian; Croatian |
| Association of the HOPA<sup>12bp</sup> allele with a large X‐chromosome haplotype and positive symptom schizophrenia |
|
|
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|
|
| Genome‐wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: Fine mapping adds support on chromosomes 6 and 11 |
|
|
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|
|
✓ |
✓ |
Portuguese Island population |
| Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits |
|
|
|
|
|
|
|
|
|
| Family‐based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3 |
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|
|
| Adrenergic alpha 2C receptor genomic organization: Association study in adult ADHD |
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|
|
| Theodore Reich, M.D.: October 14, 1938–December 25, 2003 |
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|
|
| Association of cholecystokinin‐A receptor gene polymorphisms and panic disorder in Japanese |
|
|
|
|
|
|
✓ |
✓ |
Japanese |
| μ opioid receptor gene as a candidate for the study of obsessive compulsive disorder with and without tics |
|
|
|
|
|
|
|
|
|
| Direct analysis of the genes encoding G proteins Gα<sub>T2</sub>, Gα<sub>o</sub>, Gα<sub>Z</sub> in ADHD |
|
|
|
|
|
|
|
|
|
| Association of a long‐chain fatty acid‐CoA ligase 4 gene polymorphism with depression and with enhanced niacin‐induced dermal erythema |
|
|
|
|
|
✓ |
|
|
European–Americans (EA) |
| Association between the <i>FOXP2</i> gene and autistic disorder in Chinese population |
|
|
|
|
|
|
✓ |
✓ |
Chinese Han trios; Chinese population |
| Multiple dimensions of familial psychopathology affect risk of mood disorder in children of bipolar parents |
|
|
|
|
|
|
|
|
|
| Angiotensin‐related genes in patients with panic disorder |
|
|
|
|
|
|
|
|
|
| Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (<i>GRM8</i>) with schizophrenia |
|
|
|
|
|
|
|
|
|
| Association of six polymorphisms of the <i>NOTCH4</i> gene with schizophrenia in the Japanese population |
|
|
|
|
|
|
✓ |
✓ |
Japanese population; Chinese population |
| DRD2 −141C insertion/deletion polymorphism is not associated with schizophrenia: Results of a meta‐analysis |
|
|
|
|
|
|
|
|
|
| An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, <i>HSPG2</i>) and Alzheimer's disease |
|
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|
|
|
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|
|
| Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia |
|
|
|
|
|
|
|
|
|
| Polymorphism of 5HT<sub>2A</sub> serotonin receptor gene is implicated in smoking addiction |
|
|
|
|
|
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|
|
| CAG nucleotide repeat profiles in persons with schizophrenia or schizoaffective disorders with and without tardive dyskinesia: Pilot study |
|
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|
|
|
|
|
|
|
| Childhood‐onset schizophrenia and tryptophan hydroxylase gene polymorphism |
|
|
|
|
|
|
✓ |
✓ |
Japanese |
| Statistical confirmation of negative results of association studies in genetic epidemiology |
|
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|
|
|
|
|
|
|
| Identification of families with cortical Lewy body disease |
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|
|
|
|
|
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|
|
| Association of the dopamine D5 receptor with attention deficit hyperactivity disorder (ADHD) and scores on a continuous performance test (TOVA) |
|
|
|
|
|
|
|
|
|
| Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa |
|
|
|
|
|
|
✓ |
✓ |
Japanese |
| A genome wide search for alcoholism susceptibility genes |
|
|
|
|
|
|
|
|
|
| Association between cytochrome P450 2D6 genotype and harm avoidance |
|
✓ |
|
|
|
|
|
|
|
| Lifetime achievement award 2003 |
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|
|
| Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network |
|
|
|
|
|
|
|
|
|
| Modifier effects in autism at the MAO‐A and DBH loci |
|
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|
|
|
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|
|
|
| Theodore Reich, M.D. (1938–2003): In memoriam |
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|
|
|
|
|
|
| Association between low‐activity serotonin transporter genotype and heroin dependence: Behavioral and personality correlates |
|
✓ |
|
|
|
✓ |
|
|
West European |